This chapter discusses pandemics that have occurred previously and introduces the concept of pandemic preparedness upon which subsequent chapters focus. Section headings are: prerequisites for pandemic influenza; pandemics before the 20th century; influenza pandemics of the 20th century; swine flu, 1976; re-emergence of influenza A/H1N1 in 1977; antigenic recycling in relation to human pandemics; and pandemic preparedness.