Electrochemical C–H Functionalization of Cyclic Amines

Abstract Functionalized cyclic amines are essential structural motifs in synthetic chemistry and pharmaceutical chemistry, and Shono-type oxidation is a well-developed electrochemical approach for the synthesis of α- amines. In sharp contrast, electrochemically driven direct β-C(sp3)–H functionalization of amines has been far proven elusive. Herein, we outline the recent advances in this field and highlight our group’s effort to achieve electrochemical β-C(sp3)–H functionalization assisted by ferrocene as molecular electrocatalyst under mild conditions. 1 Introduction 2 Case studies of α-Functionalization (Shono-Type Oxidation) 3 Electrochemical β-C(sp3)–H Acylation 4 Conclusion