粒径
Box-Behnken设计
生物利用度
材料科学
肺表面活性物质
再结晶(地质)
柚皮素
溶解
响应面法
原材料
析因实验
扫描电子显微镜
超声
溶剂
核化学
色谱法
化学工程
化学
有机化学
数学
复合材料
古生物学
生物信息学
统计
类黄酮
工程类
生物
抗氧化剂
作者
Xiaonan Zhang,Yan Huang,Yufei Shi,Mengyu Chen,Lubin Zhang,Yimin An,Zhiwei Liu
出处
期刊:Nanomaterials
[MDPI AG]
日期:2022-06-19
卷期号:12 (12): 2108-2108
被引量:2
摘要
Raw naringenin directly isolated from plants is significantly limited by its poor dissolution rate and low bioavailability for clinical and in vivo studies. This study reported a method for the preparation of naringenin ultrafine powder (NUP) using a novel anti-solvent recrystallization process; preliminary experiments were conducted using six single-factor experiments. The response surface Box-Behnken (BBD) design was used to optimize the level of factors. The optimal preparation conditions of the DMP were obtained as follows: the feed rate was 40.82 mL/min, the solution concentration was 20.63 mg/mL, and the surfactant ratio was 0.62%. The minimum average particle size was 305.58 ± 0.37 nm in the derived optimum conditions. A scanning electron microscope was used to compare and analyze the appearance and morphology of the powder before and after preparation. The characterization results of FTIR, TG and XRD showed that no chemical change occurred in the powder before and after preparation. Through the simulated gastrointestinal juice digestion experiment, it was confirmed that the absorption rate of NUP was 2.96 times and 4.05 times higher than raw naringenin, respectively. Therefore, the results showed that the reduction in the particle size through the use of low-speed recrystallization could improve the absorption rate and provided a feasible approach for the further applications.
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