Methods for the Catalytic Synthesis of Piperazine

Piperazine synthesis methods on intermolecular and intramolecular cyclization catalytic processes are compared and reviewed analytically. The advantages and disadvantages of current ways of synthesizing piperazine are described while focusing on the preferred and highly selective processes of intramolecular cyclization using aminoethylethanolamine and diethylenetriamine, and one-step intermolecular cyclization using ethylenediamine, mono-, and diethanolamine.