体内
去甲肾上腺素
化学
神经影像学
部分
分子成像
分子探针
离体
钆
生物物理学
体外
核磁共振
神经科学
生物化学
生物
立体化学
多巴胺
有机化学
基因
物理
生物技术
作者
Lingxuan Li,Ao Li,Yaying Lin,Dongxia Chen,Bilun Kang,Hongyu Lin,Jinhao Gao
标识
DOI:10.1002/open.202200110
摘要
Norepinephrine (NE), acting as both a neurotransmitter and hormone, plays a significant role in regulating the action of the brain and body. Many studies have demonstrated a strong correlation between mental disorders and aberrant NE levels. Therefore, it is of urgent demand to develop in vivo analytical methods of NE for diagnostic assessment and mechanistic investigations of mental diseases. Herein, we report a 19 F MRI probe (NRFP) for sensing and imaging NE, which is constructed by conjugating a gadolinium chelate to a fluorine-containing moiety through a NE-responsive aromatic thiocarbonate linkage. The capacity and specificity of NRFP for detecting NE is validated with in vitro detecting/imaging experiments. Furthermore, the feasibility of NRFP for visualizing NE in animals is illustrated by ex vivo and in vivo imaging experiments, demonstrating the promising potential of NRFP for selective detection and specific imaging of NE in deep tissues of living subjects.
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