0547 Effect of Varying Diet Intensities on Weight Loss Intervention for

One of the greatest risk factors for OSA is excess body weight. Both the prevalence and severity of OSA rise in parallel with body mass index. Weight loss has been advocated as a primary treatment option but few randomized clinic trials have been conducted. Randomized controlled trial of 40 participants using 3:3:2 allocation to low calorie diet (LCD), very low calorie diet (VLCD) and usual care (UC). LCD 12001500 kcal per day, VLCD 500-800 kcal per day and UC was simply told of risk associated with obesity and OSA then encouraged to lose weight. Weekly group sessions and group based conference calls. Physical activity gradually progressed to 300 minutes per week. Vitals, food diaries, accelerometer, questionnaires, blood testing and home sleep test performed at baseline, 3 and 9 months. Average weight loss was 4.9 lbs in UC, 21.1 lbs in the LCD and 38.6 lbs in the VLCD groups. Baseline AHI was 19, 31.9 and 27.2 in the UC, LCD and VLCD groups respectively. Three month AHI was 15.7, 17 and 6.3 in the UC, LCD and VLCD groups respectively. The change in AHI was not significant compared to baseline for UC group but p<0.05 for both other groups. Nine month data has been collected but not yet analyzed. Weight loss by LCD and VLCD were both effect interventions to induce weight loss and reduce OSA severity. SHP Pilot Grant