Laser-textured High-throughput Hydrophobic/Superhydrophobic SERS platform for fish drugs residue detection

Surface-enhanced Raman Scattering (SERS) possesses unique advantages including convenient operation, label free, simple pretreatment process, non-destructive inspection and reliable test results. Aimed at practical applications, the SERS substrates need comprehensive properties in low-cost, rapid detection, high sensitivity, uniformity, stability and universality. Facile fabrication such as laser ablation and high-throughput detection can greatly reduce the cost and improve the detection efficiency. Meanwhile, superhydrophobic surfaces can increase the sensitivity and uniformity via evaporation enrichment. Herein, we report a patterned hydrophobic/superhydrophobic SERS platform, achieving the detection of 10-14mol/L Rhodamine 6G with an effect factor up to 2.1 × 1011 and high-throughput detection for at least nine different samples simultaneously. Notably, considering the abuse of hazardous fish drugs, we further apply this platform to detect crystal violet, malachite green, methylene blue, their mixtures and the crystal violet residue on contaminated fish scales. These results demonstrate that this SERS platform can not only maintain its relatively high sensitivity but also perform excellent distinguishing ability, offering valuable information on the application fields including food safety evaluation.