脚手架
化学
组合化学
功能群
生物活性
药物发现
立体化学
有机化学
计算机科学
生物化学
体外
聚合物
数据库
标识
DOI:10.1021/acs.jafc.1c08009
摘要
Reverting the orientation of a functional group by exchanging molecular parts of it is an important scaffold hopping manipulation, as biologically active compounds and their analogs, which underwent such a transformation, are often similar in shape and physicochemical properties and therefore likely in their potency as well. This review will demonstrate, how the inversion of carboxamides, sulfonamides, carbamates, oximes, hydrazones, O,S-acetals, and ethers led to the discovery of highly active agrochemicals.
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