Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(Cell Metabolism 21, 65–80; January 6, 2015) In the original published version of this paper, the names of authors Daniel G.W. Johnston, Jian-kang Jiang, and Matthew Vander Heiden were misspelled. The correction has now been made online and above. The paper’s authors apologize for any inconvenience. Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated MacrophagesPalsson-McDermott et al.Cell MetabolismJanuary 06, 2015In BriefTLR4-activated macrophages switch their metabolism from oxidative phosphorylation to glycolysis to rapidly provide for the high energy and biosynthetic demands of infection or injury response. Palsson-McDermott identify PKM2 as a critical modulator of IL-1β production and the Warburg effect in LPS-activated macrophages, highlighting it as a target in cancer and inflammation. Full-Text PDF Open Archive