Research trends in biomedical applications of two-dimensional nanomaterials over the last decade – A bibliometric analysis

Two-dimensional (2D) nanomaterials with versatile properties have been widely applied in the field of biomedicine. Despite various studies having reviewed the development of biomedical 2D nanomaterials, there is a lack of a study that objectively summarizes and analyzes the research trend of this important field. Here, we employ a series of bibliometric methods to identify the development of the 2D nanomaterial-related biomedical field during the past 10 years from a holistic point of view. First, the annual publication/citation growth, country/institute/author distribution, referenced sources, and research hotspots are identified. Thereafter, based on the objectively identified research hotspots, the contributions of 2D nanomaterials to the various biomedical subfields, including those of biosensing, imaging/therapy, antibacterial treatment, and tissue engineering are carefully explored, by considering the intrinsic properties of the nanomaterials. Finally, prospects and challenges have been discussed to shed light on the future development and clinical translation of 2D nanomaterials. This review provides a novel perspective to identify and further promote the development of 2D nanomaterials in biomedical research.