树枝状大分子
纳米技术
DNA
适体
核酸
材料科学
生物传感器
纳米医学
DNA纳米技术
纳米颗粒
药物输送
纳米结构
纳米材料
计算生物学
基因传递
纳米载体
化学
生物
分子生物学
生物化学
作者
Li-Nan Liu,Lichi Han,Qiong-Hui Wu,Yue Sun,Ke-Han Li,Yao Liu,Hanghang Liu,En Luo
摘要
DNA nanomaterials have attracted ever-increasing attention over the past decades due to their incomparable programmability and multifunctionality. In particular, DNA dendrimer nanostructures, as a major research focus, have been applied in the fields of biosensing, therapeutics, and protein engineering, benefiting from their highly branched configuration. With the aid of specific recognition probes and inherent signal amplification, DNA dendrimers can achieve ultrasensitive detection of nucleic acids, proteins, cells, and other substances, such as lipopolysaccharides (LPS), adenosine triphosphate (ATP), and exosomes. By virtue of their void-containing structures and biocompatibility, DNA dendrimers can deliver drugs or functional nucleic acids into target cells in chemotherapy, immunotherapy, and gene therapy. Furthermore, DNA dendrimers are being applied in protein engineering for efficient directed evolution of proteins. This review summarizes the main research progress of DNA dendrimers, concerning their assembly methods and biomedical applications as well as the emerging challenges and perspectives for future research.
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