神经科学
伏隔核
扁桃形结构
基底外侧杏仁核
心理学
价(化学)
惩罚(心理学)
中枢神经系统
化学
发展心理学
有机化学
作者
Xian Zhang,Wuqiang Guan,Tao Yang,Alessandro Furlan,Xiyuan Xiao,Kai Yu,Xu An,William Galbavy,Charu Ramakrishnan,Karl Deisseroth,Kimberly Ritola,Adam W. Hantman,Miao He,Zirui Huang,Bo Li
标识
DOI:10.1038/s41593-021-00927-0
摘要
The basolateral amygdala (BLA) plays essential roles in behaviors motivated by stimuli with either positive or negative valence, but how it processes motivationally opposing information and participates in establishing valence-specific behaviors remains unclear. Here, by targeting Fezf2-expressing neurons in the BLA, we identify and characterize two functionally distinct classes in behaving mice, the negative-valence neurons and positive-valence neurons, which innately represent aversive and rewarding stimuli, respectively, and through learning acquire predictive responses that are essential for punishment avoidance or reward seeking. Notably, these two classes of neurons receive inputs from separate sets of sensory and limbic areas, and convey punishment and reward information through projections to the nucleus accumbens and olfactory tubercle, respectively, to drive negative and positive reinforcement. Thus, valence-specific BLA neurons are wired with distinctive input-output structures, forming a circuit framework that supports the roles of the BLA in encoding, learning and executing valence-specific motivated behaviors.
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