卡宾
化学
环丁酮
钯
戒指(化学)
芳基
催化作用
卤化物
组合化学
分子
偶联反应
共轭体系
联轴节(管道)
光化学
药物化学
有机化学
烷基
工程类
聚合物
机械工程
作者
Xiaoqin Ning,Yongke Chen,Fangdong Hu,Ying Xia
出处
期刊:Organic Letters
[American Chemical Society]
日期:2021-10-08
卷期号:23 (21): 8348-8352
被引量:14
标识
DOI:10.1021/acs.orglett.1c03052
摘要
Described herein are the palladium-catalyzed cross-coupling reactions of cyclobutanone-derived N-sulfonylhydrazones with aryl or benzyl halides, suggesting that the metal carbene process and β-hydride elimination can smoothly occur in strained ring systems. Structurally diversified products including cyclobutenes, methylenecyclobutanes, and conjugated dienes are selectively afforded in good to excellent yields. Preliminary success in asymmetric carbene coupling reactions in strained ring systems has been achieved, providing a promising route for the synthesis of enantioenriched four-membered-ring molecules.
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