PLGA公司
再生(生物学)
骨愈合
牙科
生物医学工程
骨组织
显著性差异
材料科学
化学
医学
外科
生物
内科学
纳米技术
细胞生物学
纳米颗粒
作者
Sanja Milutinović-Smiljanić,Dj. Antonijević,Milutin Mićić,Vladimir Biočanin,Nikola Sjerobabin,Bojan Petrović,Vesna Danilović,Vukoman Jokanović
标识
DOI:10.2298/vsp210513072m
摘要
Background/Aim. The materials used nowadays for bone replacement do not fully meet the requirements for complete regeneration, which is why new ones are being tested. Despite numerous attempts to improve bone tissue regeneration, no fulfilling material has been found yet. This study investigated the influence of poly-lactide-co-glycolide (PLGA) and polyethyleneimine (PEI) as coatings for hydroxyapatite (HAP) bone carriers on bone tissue regenerative potential in rabbits? calvarial defect. Methods. Calvarial defects measuring 6 mm in diameter were made in 19 skeletally mature rabbits. Defects were filled with one of the following materials: PLGA coated HAP (HAP + PLGA), PEI coated HAP (HAP + PEI), and bovine HAP ? Bio-Oss? (positive control). Unfilled defects represented negative control. Histological analysis was performed in order to determine the inflammatory response of the host tissue. The formation of the new bone was evaluated using histomorphometric analysis. All analyses have been conducted in samples obtained 3, 6, and 9 weeks after implantation. Results. Three weeks post-implantation, a trend toward increased healing in the HAP + PLGA group compared to other investigated materials was noticed, with no statistically significant difference between the study groups (p > 0.05). However, after 6 and 9 weeks, significant healing was observed in favor of the HAP coated with PLGA compared to other groups (p < 0.05). Within this group, greater bone healing was observed compared to the HAP + PEI and Bio-Oss? groups. Conclusion. PLGA demonstrated greater coating potential compared to PEI with respect to osteogenesis improvement in bone reconstructive surgery.
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