结直肠癌
生物
大肠癌小鼠模型的建立
肿瘤微环境
癌症
计算生物学
癌症研究
癌症遗传学
免疫系统
生物信息学
遗传学
作者
Jiexi Li,Xingdi Ma,Deepavali Chakravarti,Shabnam Shalapour,Ronald A. DePinho
出处
期刊:Genes & Development
[Cold Spring Harbor Laboratory]
日期:2021-06-01
卷期号:35 (11-12): 787-820
被引量:169
标识
DOI:10.1101/gad.348226.120
摘要
Colorectal cancer has served as a genetic and biological paradigm for the evolution of solid tumors, and these insights have illuminated early detection, risk stratification, prevention, and treatment principles. Employing the hallmarks of cancer framework, we provide a conceptual framework to understand how genetic alterations in colorectal cancer drive cancer cell biology properties and shape the heterotypic interactions across cells in the tumor microenvironment. This review details research advances pertaining to the genetics and biology of colorectal cancer, emerging concepts gleaned from immune and single-cell profiling, and critical advances and remaining knowledge gaps influencing the development of effective therapies for this cancer that remains a major public health burden.
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