FOXP3型
白细胞介素2受体
流式细胞术
化疗
免疫系统
医学
调节性T细胞
免疫学
白血病
淋巴细胞白血病
T细胞
急性白血病
细胞毒性T细胞
癌症研究
内科学
体外
生物
生物化学
作者
Marina Nayeli Medina-Rosales,Susana Godina-González,Mariana Haydee García-Hernández
出处
期刊:DOAJ: Directory of Open Access Journals - DOAJ
日期:2020-03-01
卷期号:17 (1): 87-93
标识
DOI:10.22034/iji.2020.80297
摘要
Drugs used in cancer treatment specifically kill T regulatory cells.To determine different phenotypes of T regulatory cells during the maintenance phase chemotherapy for pediatric acute lymphoblastic leukemia (ALL).We evaluated the percentages of regulatory T cells by flow cytometry. Soluble CTLA-4 (sCTLA-4) in plasma was evaluated by ELISA assay.Increased percentages of CD4+CD25+ T cells, CD4+CD39+ T cells, CD4+Foxp3+ T cells, and CD4+CD25High T cells were observed in children with ALL in comparison to healthy controls. In addition, the ALL patients with >12 months of therapy showed increased CD4+CD39+ T cells compared to the ALL patients with ≤12 months and healthy controls. Similarly, the CD4+CD25+ T cells and CD4+Foxp3+ T cells increased according to maintenance therapy time.Our results showed increased percentages of regulatory T cells in pediatric ALL patients despite chemotherapy, which might be compromising the anti-leukemic cellular immune response.
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