过氧化物酶体
脂肪甘油三酯脂肪酶
脂解
脂滴
脂滴包被蛋白
脂质代谢
化学
细胞生物学
脂肪组织
生物
细胞器
生物化学
受体
作者
Jinuk Kong,Yul Ji,Yong Geun Jeon,Ji Seul Han,Kyung Hee Han,Jung Hyun Lee,Gung Lee,Hyejeong Jang,Sung Sik Choe,Myriam Baes,Jae Bum Kim
标识
DOI:10.1038/s41467-019-14176-0
摘要
Abstract Lipid droplets (LDs) are key subcellular organelles for regulating lipid metabolism. Although several subcellular organelles participate in lipid metabolism, it remains elusive whether physical contacts between subcellular organelles and LDs might be involved in lipolysis upon nutritional deprivation. Here, we demonstrate that peroxisomes and peroxisomal protein PEX5 mediate fasting-induced lipolysis by stimulating adipose triglyceride lipase (ATGL) translocation onto LDs. During fasting, physical contacts between peroxisomes and LDs are increased by KIFC3-dependent movement of peroxisomes toward LDs, which facilitates spatial translocations of ATGL onto LDs. In addition, PEX5 could escort ATGL to contact points between peroxisomes and LDs in the presence of fasting cues. Moreover, in adipocyte-specific PEX5-knockout mice, the recruitment of ATGL onto LDs was defective and fasting-induced lipolysis is attenuated. Collectively, these data suggest that physical contacts between peroxisomes and LDs are required for spatiotemporal translocation of ATGL, which is escorted by PEX5 upon fasting, to maintain energy homeostasis.
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