Novel polymeric micelles as enzyme-sensitive nuclear-targeted dual-functional drug delivery vehicles for enhanced 9-nitro-20(S)-camptothecin delivery and antitumor efficacy

Antitumor drug 9-NC was loaded in the HA based micelles 9-NC/HATPC, which were targeted to tumor and dissociated into secondary micelles 9-NC/TPC in lysosomes in tumor cells and then it could delivery 9-NC directly to the cell “heart”.