生殖毒性
生物
毒性
氧化应激
程序性细胞死亡
发育毒性
表观遗传学
细胞生物学
细胞凋亡
后代
内质网
医学
内科学
内分泌学
怀孕
胎儿
生物化学
遗传学
基因
作者
Shiyu Zhang,Xingde Du,Haohao Liu,Michael D. Losiewic,Xinghai Chen,Yu Ma,Rui Wang,Zhigang Tian,Linjia Shi,Haipeng Guo,Huizhen Zhang
标识
DOI:10.1016/j.envres.2020.110254
摘要
Microcystin-LR (MC-LR) is an emerging environmental pollutant produced by cyanobacteria that poses a threat to wild life and human health. In recent years, the reproductive toxicity of MC-LR has gained widespread attention, a large number of toxicological studies have filled the gaps in past research and more molecular mechanisms have been elucidated. Hence, this paper reviews the latest research advances on MC-LR-induced reproductive toxicity. MC-LR can damage the structure and function of the testis, ovary, prostate, placenta and other organs of animals and then reduce their fertility. Meanwhile, MC-LR can also be transmitted through the placenta to the offspring causing trans-generational and developmental toxicity including death, malformation, growth retardation, and organ dysfunction in embryos and juveniles. The mechanisms of MC-LR-induced reproductive toxicity mainly include the inhibition of protein phosphatase 1/2 A (PP1/2 A) activity and the induction of oxidative stress. On the one hand, MC-LR triggers the hyperphosphorylation of certain proteins by inhibiting intracellular PP1/2 A activity, thereby activating multiple signaling pathways that cause inflammation and blood-testis barrier destruction, etc. On the other hand, MC-LR-induced oxidative stress can result in cell programmed death via the mitochondrial and endoplasmic reticulum pathways. It is worth noting that epigenetic modifications are also involved in reproductive cell apoptosis, which may be an important direction for future research. Furthermore, this paper proposes for the first time that MC-LR can produce estrogenic effects in animals as an environmental estrogen. New findings and suggestions in this review could be areas of interest for future research.
科研通智能强力驱动
Strongly Powered by AbleSci AI