富血小板血浆
血小板
骨愈合
生物医学工程
动物模型
化学
医学
病理
解剖
内科学
作者
S. Skwarcz,I. Bryzek,A Gregosiewicz,E Warda,Krzysztof Gaweda,Marta Tarczyńska,J. Skwarcz,R. Nadulski,A. Starek,Joanna Sanford
出处
期刊:Polish Journal of Veterinary Sciences
[De Gruyter]
日期:2023-07-26
标识
DOI:10.24425/pjvs.2019.127092
摘要
The purpose of the study was to assess the effect of autologous activated platelet-rich plasma on healing of a bone substitute - tricalcium phosphate hydroxyapatite in experimental long bone defects using an animal model. The experiment involved an animal model of femoral defect. 24 Termond white rabbits were used in the study. We evaluated the effect of autologous platelet-rich plasma on tricalcium phosphate using classical radiology, micro-CT studies, strength tests and histological evaluation. Radiological and histological assessment did not show a beneficial effect of PRP together with a bone substitute in comparison to filling the defects only with bone replacement material. The only benefit of adding platelet-rich plasma to a bone substitute was shown in microCT imaging. Autologous, activated platelet-rich plasma combined with hydroxyapatite tricalcium phosphate has a positive effect on the remodeling of the newly formed bone tissue, increasing its density.
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