AB1302-HPR ASSOCIATIONS OF SLEEP ON GOUT PREVALENCE AND SERUM URIC ACID CONCENTRATIONS

Background: Sleep deprivation and sleep inconsistency have been associated with modulation of the immune and inflammatory response systems with effects that include higher risk for psychosis, cardiovascular disease, and increased susceptibility to infection. One hypothesized mechanism to explain these findings is an association with pro-inflammatory states. Objectives: In a first-of-its kind study, we examined associations between sleep quantity and gout using the largest public US dataset available; the National Health and Nutrition Examination Survey (NHANES). Methods: NHANES data from 2009 to 2014 was selected based on questionnaire responses and laboratory studies. The resulting data set was analyzed for serum uric acid (SUA) levels (cut-off >6.0 mg/dL in females and >7.0 mg/dL in males), and gout risk factors. Analysis of variance, means, proportions, as well as univariate and multiple logistic regression models were used to evaluate the associations between sleep quantity, SUA and gout. Results: 10,410 survey participants from 2003 to 2014 were included in the study. A total of 280 (2.7%) had gout. Gout prevalence ranged between 4.0% and 4.7% between high, normal, and low sleep groups. Multivariate analyses showed a significant association between extremely low sleep levels (OR = 0.53 and CI = 0.34 to 0.83), and gout, which was also seen with SUA level association (OR = 0.41 and CI = 0.32 to 0.52). However, in the broader sense, lower than normal (<7 hours) and higher than normal (>9 hours) levels of sleep had no significant associations with either gout prevalence or SUA, likely due to a non-linear relationship of SUA to sleep levels. Conclusion: Despite numerous adverse effects found with low sleep levels, our study does not show a strong association between sleep quantity and gout prevalence or SUA levels. References: [1]Hasday et al. “ Nocturnal increase of urinary uric acid: creatinine ration. A biological correlate of sleep-associated hypoxemia .” AM Rev Respir Dis 1981, 135:534 [2]Lavie, Lena. “ Obstructive sleep apnoea syndrome-an oxidative stress disorder ” Sleep Medicine Reviews 2003, 7:35 1 [3]Roddy et al. “ The Association of Gout with Sleep Disorders: a cross-sectional study in primary care. ”BMC Musculoskeletal Disorders 2013, 14:119 [4]Sahebjani H. “ Changes in urinary uric acid excretion in obstructive sleep apean before and after therapy with nasal continuous positive airway pressure .” Chest 1998’ 113: 1604 [5]Taheri et al. “ Short Sleep Duration is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index ” PLOS Medicine 2004, 1:210 Disclosure of Interests: None declared