Enhancing analgesic spinal cord stimulation for chronic pain with personalized immersive virtual reality

止痛药 虚拟现实 医学 慢性疼痛 脊髓刺激 神经病理性疼痛 脊髓 物理医学与康复 神经刺激 麻醉 物理疗法 刺激 神经调节 内科学 计算机科学 人机交互 精神科
作者
Marco Solcà,Vibhor Krishna,Nicole A. Young,Milind Deogaonkar,Bruno Herbelin,Pavo Orepić,Robin Mange,Giulio Rognini,Andrea Serino,Ali R. Rezai,Olaf Blanke
出处
期刊:Pain [Lippincott Williams & Wilkins]
卷期号:162 (6): 1641-1649 被引量:24
标识
DOI:10.1097/j.pain.0000000000002160
摘要

Abstract Spinal cord stimulation (SCS) is an approved treatment for truncal and limb neuropathic pain. However, pain relief is often suboptimal and SCS efficacy may reduce over time, requiring sometimes the addition of other pain therapies, stimulator revision, or even explantation. We designed and tested a new procedure by combining SCS with immersive virtual reality (VR) to enable analgesia in patients with chronic leg pain. We coupled SCS and VR by linking SCS-induced paresthesia with personalized visual bodily feedback that was provided by VR and matched to the spatiotemporal patterns of SCS-induced paresthesia. In this cross-sectional prospective interventional study, 15 patients with severe chronic pain and an SCS implant underwent congruent SCS-VR (personalized visual feedback of the perceived SCS-induced paresthesia displayed on the patient's virtual body) and 2 control conditions (incongruent SCS-VR and VR alone). We demonstrate the efficacy of neuromodulation-enhanced VR for the treatment of chronic pain by showing that congruent SCS-VR reduced pain ratings on average by 44%. Spinal cord stimulation–VR analgesia was stronger than that in both control conditions (enabling stronger analgesic effects than incongruent SCS-VR analgesia or VR alone) and kept increasing over successive stimulations, revealing the selectivity and consistency of the observed effects. We also show that analgesia persists after congruent SCS-VR had stopped, indicating carry over effects and underlining its therapeutic potential. Linking latest VR technology with recent insights from the neuroscience of body perception and SCS neuromodulation, our personalized new SCS-VR platform highlights the impact of immersive digiceutical therapies for chronic pain. Registration: clinicaltrials.gov, Identifier: NCT02970006.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
欢呼的鲂完成签到,获得积分10
刚刚
刚刚
1秒前
猪猪hero应助甜甜友容采纳,获得10
1秒前
jasmine完成签到,获得积分10
2秒前
竹又完成签到 ,获得积分10
2秒前
VirSnorlax完成签到,获得积分10
5秒前
6秒前
6秒前
jojo发布了新的文献求助10
7秒前
深情安青应助yujiayou采纳,获得30
7秒前
7秒前
加油的老赵完成签到,获得积分10
7秒前
甜蜜阑悦发布了新的文献求助10
9秒前
平常的毛豆应助Lucy采纳,获得10
9秒前
liufan完成签到 ,获得积分10
9秒前
大模型应助盼夏采纳,获得30
10秒前
光亮萤发布了新的文献求助10
11秒前
12秒前
fengzi151完成签到,获得积分10
14秒前
15秒前
lanruoqi完成签到,获得积分10
15秒前
lilin发布了新的文献求助30
17秒前
18秒前
张怀民完成签到 ,获得积分20
18秒前
赖建琛完成签到 ,获得积分10
19秒前
Victor完成签到,获得积分10
19秒前
LYL应助自然的书易采纳,获得10
20秒前
斯文败类应助南北采纳,获得30
20秒前
Junli完成签到,获得积分10
22秒前
chaoshen完成签到,获得积分10
23秒前
24秒前
24秒前
栗栗子发布了新的文献求助10
24秒前
25秒前
简直乖惨了完成签到 ,获得积分10
25秒前
26秒前
彭于彦祖应助加油的老赵采纳,获得20
26秒前
TianFuAI发布了新的文献求助10
29秒前
向初晴发布了新的文献求助10
29秒前
高分求助中
Chinesen in Europa – Europäer in China: Journalisten, Spione, Studenten 500
Arthur Ewert: A Life for the Comintern 500
China's Relations With Japan 1945-83: The Role of Liao Chengzhi // Kurt Werner Radtke 500
Two Years in Peking 1965-1966: Book 1: Living and Teaching in Mao's China // Reginald Hunt 500
Epigenetic Drug Discovery 500
Hardness Tests and Hardness Number Conversions 300
Knowledge management in the fashion industry 300
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3816877
求助须知:如何正确求助?哪些是违规求助? 3360272
关于积分的说明 10407488
捐赠科研通 3078282
什么是DOI,文献DOI怎么找? 1690682
邀请新用户注册赠送积分活动 813990
科研通“疑难数据库(出版商)”最低求助积分说明 767958