Histopathologic Evaluation of Ecballium Elaterium Applied Nasal Mucosa in Rat Rhinosinusitis Model

This study aims to evaluate the antimicrobial effects of Ecballium Elaterium (E.E) that is topically applied for treatment of rhinosinusitis as a traditional medicine. Pure and extract forms of E.E are applied to the nasal cavity of rats for rhinosinusitis. Nasal mucosa, soft palate and trachea of rats were harvested in the first hour, 3 rd day and 3 rd week for histopathological evaluation. This experimental study revealed antiinflammatory effects of E.E. It has also been shown that E.E reduced fibrosis. The antiinflammatory effect of all forms of E.E has been found to be at their maximum level in the 3 rd day with a decreasing manner to 3 rd week. Additionally, pure form of E.E caused severe epithelial loss in hyperacute stage. E.E also reduced fibrosis besides its antiinflammatory effect. The action mechanism of antiinflammatory effect of different levels of extract forms need to be further analysed through related enzymatic pathways by different dose and time studies.