冠状病毒
中枢神经系统
爆发
严重急性呼吸综合征冠状病毒2型(SARS-CoV-2)
传染性
2019年冠状病毒病(COVID-19)
医学
倍他科诺病毒
疾病
呼吸系统
免疫学
病毒学
生物
病理
病毒
传染病(医学专业)
内科学
作者
Qi Cheng,Yue Yang,Jianqun Gao
出处
期刊:EBioMedicine
[Elsevier]
日期:2020-06-01
卷期号:56: 102799-102799
被引量:65
标识
DOI:10.1016/j.ebiom.2020.102799
摘要
Abstract
A new strain of human coronaviruses (hCoVs), Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been identified to be responsible for the current outbreak of the coronavirus disease 2019 (COVID-19). Though major symptoms are primarily generated from the respiratory system, neurological symptoms are being reported in some of the confirmed cases, raising concerns of its potential for intracranial invasion and neurological manifestations, both in the acute phase and in the long-term. At present, it remains unclear the extent to which SARS-CoV-2 is present in the brain, and if so, its pathogenic role in the central nervous system (CNS). Evidence for neuroinvasion and neurovirulence of hCoVs has been recognised in animal and human studies. Given that SARS-CoV-2 belongs to the same family and shares characteristics in terms of receptor binding properties, it is worthwhile exploring its potential CNS manifestations. This review summarises previous findings from hCoVs in relation to the CNS, and compares these with the new strain, aiming to provide a better understanding of the effects of SARS-CoV-2 on the CNS.
科研通智能强力驱动
Strongly Powered by AbleSci AI