化学
昆虫病原真菌
组蛋白脱乙酰酶抑制剂
色氨酸
组蛋白脱乙酰基酶
预酸化
异羟肟酸
肟
生物化学
立体化学
组蛋白
酶
植物
氨基酸
生物病虫害防治
球孢白僵菌
基因
生物
作者
Toshinobu Asai,Takashi Yamamoto,Yoshiteru Oshima
标识
DOI:10.1016/j.tetlet.2011.10.020
摘要
Suberoyl bis-hydroxamic acid (SBHA), a histone deacetylase (HDAC) inhibitor, led to significant changes in the secondary metabolism of an entomopathogenic fungus, Torrubiella luteorostrata, and induced the production of three new prenylated tryptophan analogs, luteorides A–C (1–3). The structures are characterized by the presence of an (E)-oxime group, which is an unusual functional group in natural products, and a 3-methylbuta-1,3-dienyl unit as a common substituent. The method of culturing entomopathogenic fungi in the presence of HDAC inhibitors, such as SBHA, is convenient and attractive for obtaining novel secondary metabolites.
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