骨桥蛋白
凝血酶
癌症研究
血栓调节蛋白
肝细胞癌
医学
转移
组织因子
内科学
病理
癌症
凝结
血小板
作者
Yuhua Xue,Xiaofei Zhang,Qiongzhu Dong,Jian Sun,Chun Dai,Haijun Zhou,Ning Ren,Hu‐Liang Jia,Qin-Hai Ye,Lun–Xiu Qin
出处
期刊:Hepatology
[Lippincott Williams & Wilkins]
日期:2010-08-31
卷期号:52 (6): 2012-2022
被引量:55
摘要
Thrombin plays an important role in OPN-mediated aggressive phenotype of HCC through activation of integrin β1-FAK signaling, and is an independent poor prognostic factor for HCC. Thus, thrombin may be a potential therapeutic target to inhibit HCC metastasis in OPN+ patients.
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