萎缩
认知
痴呆
心理学
神经心理学
认知功能衰退
神经科学
听力学
医学
内科学
疾病
作者
Jamie Yu Jin Thong,Saima Hilal,Han Li,Hock Wei Soon,Yi Dong,Simon L. Collinson,Tuan Ta Anh,M. Kamran Ikram,Tien Yin Wong,Narayanaswamy Venketasubramanian,Christopher Chen,Anqi Qiu
标识
DOI:10.1136/jnnp-2013-305310
摘要
Silent lacunar infarct (SLI) is associated with cognitive decline and linked to an increased risk of stroke and dementia. We examined the association of SLI with MRI measures of cortical thickness, subcortical and lateral ventricular shapes and cognition in 285 ethnic Chinese elderly.SLI, cortical thickness, shapes of subcortical and ventricular structures were quantified using MRI. The cognitive performance was assessed using comprehensive neuropsychological tests. Linear regression was used to examine associations among SLI, brain measures and cognition.SLI was associated with atrophy in multiple subcortical structures, ventricular enlargement and widespread cortical thinning. Both SLI and atrophy were independently related to poorer performance in attention, memory and language domains. Only SLI was associated with visuomotor speed and executive function, while atrophy mediated the association between SLI and visuoconstruction.Our findings support a vascular contribution to neurodegeneration and cognitive impairment.
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