Increase of total creatine in human brain after oral supplementation of creatine-monohydrate

肌酸 一水肌酸 医学 内科学 内分泌学 安慰剂 病理 替代医学
作者
Peter Dechent,Petra J. W. Pouwels,B. Wilken,F. Hanefeld,Jens Frahm
出处
期刊:American Journal of Physiology-regulatory Integrative and Comparative Physiology [American Physiological Society]
卷期号:277 (3): R698-R704 被引量:206
标识
DOI:10.1152/ajpregu.1999.277.3.r698
摘要

The effect of oral creatine supplementation on brain metabolite concentrations was investigated in gray matter, white matter, cerebellum, and thalamus of healthy young volunteers by means of quantitative localized proton magnetic resonance spectroscopy in vivo (2.0 T, stimulated echo acquisition mode sequence; repetition time = 6,000 ms, echo time = 20 ms, middle interval = 10 ms, automated spectral evaluation). Oral consumption of 4 x 5 g creatine-monohydrate/day for 4 wk yielded a statistically significant increase (8.7% corresponding to 0.6 mM, P < 0.001) of the mean concentration of total creatine (tCr) when averaged across brain regions and subjects (n = 6). The data revealed considerable intersubject variability (3.5-13.3%), with the smallest increases observed for the two male volunteers with the largest body weights. A regional analysis resulted in significant increases of tCr in gray matter (4.7%), white matter (11.5%), and cerebellum (5.4%) and was most pronounced in thalamus (14.6% corresponding to 1.0 mM). Other findings were significant decreases of N-acetyl-containing compounds in cerebellum and thalamus as well as of choline-containing compounds in thalamus. All cerebral metabolic alterations caused by oral Cr were reversible, as evidenced by control measurements at least 3 mo after the diet. This work demonstrates that excess consumption of Cr yields regionally dependent increases of the tCr concentration in human brain over periods of several weeks.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
苹果发布了新的文献求助50
1秒前
完美世界应助kurtlin采纳,获得10
1秒前
2秒前
3秒前
3秒前
4秒前
4秒前
顾己发布了新的文献求助10
5秒前
勤恳的雪卉完成签到,获得积分0
6秒前
彭甜发布了新的文献求助10
7秒前
7秒前
8秒前
8秒前
9秒前
大模型应助王旭东采纳,获得10
10秒前
在水一方应助111采纳,获得10
11秒前
乔治哇发布了新的文献求助10
11秒前
阿欢完成签到 ,获得积分10
11秒前
Ann发布了新的文献求助10
12秒前
13秒前
顾己完成签到,获得积分10
13秒前
13秒前
阳光发布了新的文献求助10
14秒前
14秒前
上官若男应助大方研究生采纳,获得10
14秒前
叶黄戍发布了新的文献求助10
16秒前
20秒前
叶黄戍完成签到,获得积分10
21秒前
22秒前
24秒前
jin发布了新的文献求助10
24秒前
25秒前
25秒前
26秒前
Hello应助风中思松采纳,获得10
27秒前
TOO完成签到 ,获得积分10
28秒前
JamesPei应助lgj采纳,获得10
28秒前
王旭东发布了新的文献求助10
28秒前
高贵白凝发布了新的文献求助10
29秒前
ZZY发布了新的文献求助200
29秒前
高分求助中
Les Mantodea de Guyane Insecta, Polyneoptera 2500
Technologies supporting mass customization of apparel: A pilot project 450
China—Art—Modernity: A Critical Introduction to Chinese Visual Expression from the Beginning of the Twentieth Century to the Present Day 430
Tip60 complex regulates eggshell formation and oviposition in the white-backed planthopper, providing effective targets for pest control 400
A Field Guide to the Amphibians and Reptiles of Madagascar - Frank Glaw and Miguel Vences - 3rd Edition 400
China Gadabouts: New Frontiers of Humanitarian Nursing, 1941–51 400
The Healthy Socialist Life in Maoist China, 1949–1980 400
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3791108
求助须知:如何正确求助?哪些是违规求助? 3335778
关于积分的说明 10276931
捐赠科研通 3052392
什么是DOI,文献DOI怎么找? 1675123
邀请新用户注册赠送积分活动 803106
科研通“疑难数据库(出版商)”最低求助积分说明 761076