点击化学
化学
三唑
杂原子
组合化学
模块化设计
纳米技术
生物相容性
有机化学
计算机科学
材料科学
操作系统
戒指(化学)
作者
John E. Moses,Adam D. Moorhouse
摘要
Click chemistry, the subject of this tutorial review, is a modular synthetic approach towards the assembly of new molecular entities. This powerful strategy relies mainly upon the construction of carbon–heteroatom bonds using spring-loaded reactants. Its growing number of applications are found in nearly all areas of modern chemistry from drug discovery to materials science. The copper(I)-catalysed 1,2,3-triazole forming reaction between azides and terminal alkynes has become the gold standard of click chemistry due to its reliability, specificity and biocompatibility.
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