单域抗体
计算生物学
领域(数学分析)
双特异性抗体
重组DNA
计算机科学
重链
抗体
单克隆抗体
生物
遗传学
数学
基因
数学分析
作者
Thomas Meyer,Serge Muyldermans,Ann Depicker
标识
DOI:10.1016/j.tibtech.2014.03.001
摘要
•New production platforms for VHH and VHH-Fc antibodies were recently explored. •VHHs have distinct properties and often outperform conventional antibodies. •Several VHHs for protein purification and localisation are commercially available. Since the serendipitous discovery 20 years ago of bona fide camelid heavy-chain antibodies, their single-domain antigen-binding fragments, known as VHHs or nanobodies, have received a progressively growing interest. As a result of the beneficial properties of these stable recombinant entities, they are currently highly valued proteins for multiple applications, including fundamental research, diagnostics, and therapeutics. Today, with the original patents expiring, even more academic and industrial groups are expected to explore innovative VHH applications. Here, we provide a thorough overview of novel implementations of VHHs as research and diagnostic tools, and of the recently evaluated production platforms for several VHHs and VHH-derived antibody formats. Since the serendipitous discovery 20 years ago of bona fide camelid heavy-chain antibodies, their single-domain antigen-binding fragments, known as VHHs or nanobodies, have received a progressively growing interest. As a result of the beneficial properties of these stable recombinant entities, they are currently highly valued proteins for multiple applications, including fundamental research, diagnostics, and therapeutics. Today, with the original patents expiring, even more academic and industrial groups are expected to explore innovative VHH applications. Here, we provide a thorough overview of novel implementations of VHHs as research and diagnostic tools, and of the recently evaluated production platforms for several VHHs and VHH-derived antibody formats.
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