Anti‐MRSA Agent Discovery Using Diversity‐Oriented Synthesis

Beating the superbugs: Diversity-oriented synthesis using a solid-supported phosphonate unit to synthesize 242 drug-like compounds based on 18 natural-product-like scaffolds led to the discovery of gemmacin (see scheme). This new structural class of antibiotic is active towards methicillin-resistant Staphylococcus aureus (MRSA). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z705415_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.