抗辐射性
己糖激酶
糖酵解
癌症研究
癌细胞
癌症
PI3K/AKT/mTOR通路
肌醇
小RNA
生物
化学
新陈代谢
内科学
生物化学
放射治疗
基因
医学
受体
细胞凋亡
遗传学
作者
Joong Won Min,Kwang Il Kim,Hyun-Ah Kim,Eun‐Kyu Kim,Woo Chul Noh,Hong Bae Jeon,Dong‐Hyung Cho,Jeong Su Oh,In-Chul Park,Sang‐Gu Hwang,Jae-Sung Kim
标识
DOI:10.1016/j.bbrc.2013.09.041
摘要
Inositol polyphosphate 4-phosphatase type II (INPP4B) was recently identified as a tumor resistance factor in laryngeal cancer cells. Herein, we show that INPP4B-mediated resistance is associated with increased glycolytic phenotype. INPP4B expression was induced by hypoxia and irradiation. Intriguingly, overexpression of INPP4B enhanced aerobic glycolysis. Of the glycolysis-regulatory genes, hexokinase 2 (HK2) was mainly regulated by INPP4B and this regulation was mediated through the Akt-mTOR pathway. Notably, codepletion of INPP4B and HK2 markedly sensitized radioresistant laryngeal cancer cells to irradiation or anticancer drug. Moreover, INPP4B was significantly associated with HK2 in human laryngeal cancer tissues. Therefore, these results suggest that INPP4B modulates aerobic glycolysis via HK2 regulation in radioresistant laryngeal cancer cells.
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