间充质
生物
输尿管芽
形态发生
肾脏发育
细胞生物学
解剖
骨形态发生蛋白4
上皮
入侵
基因
遗传学
细胞分化
胚胎
胚胎发生
原肠化
胚胎干细胞
作者
Georgina Caruana,Luise A. Cullen‐McEwen,Amy L Nelson,Xenia Kostoulias,Kyra Woods,Brooke Gardiner,Melissa J. Davis,Darrin Taylor,Rohan D. Teasdale,Sean M. Grimmond,Melissa H. Little,John F. Bertram
标识
DOI:10.1016/j.modgep.2006.02.001
摘要
The E11.5 mouse metanephros is comprised of a T-stage ureteric epithelial tubule sub-divided into tip and trunk cells surrounded by metanephric mesenchyme (MM). Tip cells are induced to undergo branching morphogenesis by the MM. In contrast, signals within the mesenchyme surrounding the trunk prevent ectopic branching of this region. In order to identify novel genes involved in the molecular regulation of branching morphogenesis we compared the gene expression profiles of isolated tip, trunk and MM cells using Compugen mouse long oligo microarrays. We identified genes enriched in the tip epithelium, sim-1, Arg2, Tacstd1, Crlf-1 and BMP7; genes enriched in the trunk epithelium, Innp1, Itm2b, Mkrn1, SPARC, Emu2 and Gsta3 and genes spatially restricted to the mesenchyme surrounding the trunk, CSPG2 and CV-2, with overlapping and complimentary expression to BMP4, respectively. This study has identified genes spatially expressed in regions of the developing kidney involved in branching morphogenesis, nephrogenesis and the development of the collecting duct system, calyces, renal pelvis and ureter.
科研通智能强力驱动
Strongly Powered by AbleSci AI