腺苷酸激酶
环化酶
磷酸二酯酶
基因亚型
蛋白激酶A
信号
PDE10A型
细胞生物学
化学
酶
信号转导
生物化学
生物
激酶
基因
作者
Miles D. Houslay,Graeme Milligan
标识
DOI:10.1016/s0968-0004(97)01050-5
摘要
Multiple forms of cAMP phosphodiesterases (PDE), adenylate cyclase and protein kinase A (PKA) allow cells to tailor the responsiveness of the cAMP-signalling system and to allow for its dynamic adjustment. Multiple forms of these enzymes confer spatial and temporal characteristics on cAMP signalling so as to affect compartmentalised responses within a single cell type. The ability to breach the PKA activation threshold can depend upon either or both the activation of adenylate cyclase and inhibition of specific PDE isoforms.
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