生物
胚胎干细胞
细胞生物学
细胞分化
内皮干细胞
诱导剂
成纤维细胞生长因子
祖细胞
干细胞
调节器
分子生物学
基因
遗传学
体外
受体
作者
Lei Han,Jing Shao,Le Su,Jiangang Gao,Shengqing Wang,Yun Zhang,Shangli Zhang,Bao‐Xiang Zhao,Miao Jiang
出处
期刊:Stem Cells and Development
[Mary Ann Liebert]
日期:2012-10-10
卷期号:21 (15): 2762-2769
被引量:18
标识
DOI:10.1089/scd.2012.0055
摘要
Embryonic stem cells (ESCs) can differentiate to endothelial progenitor cells and vascular endothelial cells (VECs), but the mechanism is largely unknown. In this study, we synthesized 2 chiral compounds (R-ABO and S-ABO) and identified R-ABO as an effective inducer of ESC differentiation into VECs. Furthermore, we found that R-ABO induced ESC differentiation into VECs via homeobox containing 1 (Hmbox1) that acted upstream of fibroblast growth factor 2 (FGF-2). The data suggest that R-ABO is a novel tool for ESC differentiation into VECs, and Hmbox1 is a key regulator in this differentiation process. These findings provide information on a novel target and a new platform for further investigating the gene control of ESC differentiation to VECs.
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