化学
卟啉
选择性
细胞凋亡
组合化学
癌症研究
癌症
纳米技术
药理学
生物化学
医学
内科学
材料科学
催化作用
作者
Lizhen He,Tianfeng Chen,Yi You,Hao Hu,Wenjie Zheng,Wai‐Lun Kwong,Taotao Zou,Chi‐Ming Che
标识
DOI:10.1002/anie.201407143
摘要
Construction of delivery systems for anticancer gold complexes to decrease their toxicity while maintaining efficacy is a key strategy to optimize and develop anticancer gold medicines. Herein, we describe cancer-targeted mesoporous silica nanoparticles (MSN) for delivery of a gold(III) porphyrin complex (Au-1 a@MSN(R)) to enhance its anticancer efficacy and selectivity between cancer and normal cells. Encapsulation of Au-1 a within mesoporous silica nanoparticles amplifies its inhibitory effects on thioredoxin reductase (TrxR), resulting in a loss of redox balance and overproduction of reactive oxygen species (ROS). Elevated cellular oxidative stress activates diversified downstream ROS-mediated signaling pathways, leading to enhanced apoptosis-inducing efficacy.
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