白细胞介素-3受体
浆细胞样树突状细胞
生物
树突状细胞
髓样
免疫学
TLR7型
癌症研究
Toll样受体
免疫系统
先天免疫系统
作者
Haisheng Yu,Peng Zhang,Xiangyun Yin,Zhang Yin,Qi Shi,Ya Cui,Guanyuan Liu,Shouli Wang,Pier Paolo Piccaluga,Taijiao Jiang,Liguo Zhang
出处
期刊:Protein & Cell
[Springer Nature]
日期:2015-03-18
卷期号:6 (4): 297-306
被引量:29
标识
DOI:10.1007/s13238-015-0140-x
摘要
Dendritic cells (DCs) comprise two functionally distinct subsets: plasmacytoid DCs (pDCs) and myeloid DCs (mDCs). pDCs are specialized in rapid and massive secretion of type I interferon (IFN-I) in response to nucleic acids through Toll like receptor (TLR)-7 or TLR-9. In this report, we characterized a CD56(+) DC population that express typical pDC markers including CD123 and BDCA2 but produce much less IFN-I comparing with pDCs. In addition, CD56(+) DCs cluster together with mDCs but not pDCs by genome-wide transcriptional profiling. Accordingly, CD56(+) DCs functionally resemble mDCs by producing IL-12 upon TLR4 stimulation and priming naïve T cells without prior activation. These data suggest that the CD56(+) DCs represent a novel mDC subset mixed with some pDC features. A CD4(+)CD56(+) hematological malignancy was classified as blastic plasmacytoid dendritic cell neoplasm (BPDCN) due to its expression of characteristic molecules of pDCs. However, we demonstrated that BPDCN is closer to CD56(+) DCs than pDCs by global gene-expression profiling. Thus, we propose that the CD4(+)CD56(+) neoplasm may be a tumor counterpart of CD56(+) mDCs but not pDCs.
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