Hyaluronic Acid Content of the Interstitial Fluid of Walker Carcinoma 256

The interstitial fluid of Walker carcinoma transplanted into Sprague-Dawley rats was sampled in vivo and compared with the interstitial fluid of the subcutaneous area where the tumor was transplanted. Hyaluronic acid was the only mucopolysaccharide present in both fluids. In the normal subcutaneous tissue the fluid of the scapular region had 45% more hyaluronic acid than the fluid of the lumbar region. Development of the tumor depressed the hyaluronic acid content about 45% in the lumbar region where it grew, and about 25% in the scapular region which was distant from the tumor mass.