化学
石墨烯
生物物理学
光化学
氧化物
光致发光
作者
Su-Ji Jeon,Seon-Yeong Kwak,DaBin Yim,Jong-Min Ju,Jong-Ho Kim
摘要
Designing artificial nanomaterials capable of selectively detecting targets without the use of expensive and fragile antibodies is of great interest in the applications of nanomedicine. Here, we show that the photoluminescence (PL) of graphene oxide (GO) was chemically modulated for the selective detection of a neurotransmitter without the use of antibodies. GO was functionalized with nitrotriacetic acid (NTA) on which four different metal ions were chelated (M-NTA-GO), which led to its different PL responses to neurotransmitters. In particular, the Cu-NTA-GO hybrid was able to selectively detect norepinephrine at nanomolar concentrations in a simple manner via its turn-on PL. Moreover, it was successfully applied to the selective detection of norepinephrine secreted from living PC-12 cells.
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