Screening of serum uric acid-lowering Lactic acid bacteria and its effect on hyperuricemia in rat models

Objective To propose a method for the prevention and treatment of hyperuricemia by Lactic acid bacteria(LAB) with specific activity,and screen LAB strains with high serum uric acid-lowering activity.Methods Based on RP-HPLC method,the changes of inosine and guanosine contents in the culture medium before and after cultivation were determined;The LAB strains which presented the fastest rates of decomposition of nucleosides were selected as the candidate strains,and administered to the model rats.The effect of the strains on the serum uric acid level of the rats were observed.Results The strain DM9218 with an optimal decomposition rate of nucleoside was obtained.Animal experimental results showed that the serum uric acid level of DM9218 intervention group [(219.25 ± 21.98) μmol/L] was obviously lower than that of the model group [(311.75 ± 27.07) μmol/L](P0.05).Conclusion DM9218 has the fastest decomposition rate of nucleosides and obvious effect of lowering serum uric acid in hyperuricemia rats.DM9218 is identified as Lactobacillus plantarum.