Objective:Classified HBV DNA of AsC of children and their parents. Methods:Using a genotyping method of based on the restriction fragment length polymorphism (RFLP) of amplified segment of the HBV S region.Results: Among the AsC of children living in Guangzhou,genotype B is 62.7%,genotype C is 33.3%,genotype B and C is 3.3%,only 1.7% could not be classified.Conclusion:The method for genotyping is simple and conveniat,the prevalent HBV strain in Guangzhou is genotype B and genotype C.