Clinical study of non-Hodgkin's lymphoma patient treated with home-made epirubicin-based regimen

Objective To observe the clinical effectiveness and toxicity of combined chemotherapy regimen containing home-made epirubicin(EPI) in the treatment of non-Hodgkin's lymphoma(NHL).Methods Thirty-seven cases were assigned to the experiment group.They were treated with cyclophosphamide(CTX)750 mg/(m~2·d),iv,d1;home-made epirubicin(EPI) 70 mg/(m~2·d),iv,d1;vincristine(VCR)(1.4 mg/)(m~2·d),iv,d1;prednisone 60 mg/(m~2·d),po,d1-5.Twenty-one days constituted one course of treatment and four or more theraputic courses were given.The control group included 38 cases of non-Hodgkin lymphoma and was treated with imported epirubicin(EPI)in stead of home-made epirubicin(EPI),other medication was same as the experiment group.Results The complete remission(CR)rate was 43.2%(16/37)and partly remission(PR) rate was 37.8%(14/37)with the overall response rate being 81.1% in the experiment group.The effectiveness was similar with no statistical difference between the two groups(P0.05).The major toxic reactions were myelosuppression with incidences of grade-Ⅰ-Ⅱ neutropenia being 59.5% and 60.5%,grade-Ⅰ-Ⅱ nausea and vomiting with incidences being 67.6% and 68.4%,the incidences of mild cardiotoxicity were 8.1% and 7.9% and alopecia accounted for 94.6% and 94.7% in the 2 groups,respectively.Conclusion The efficacy and toxicity of home-made epirubicin-based regimen and imported epirubicin-based regimen were similar in treatment of non-Hodgkin′s lymphoma.The home-made epirubicin is,therefore,deserved to be spreaded and applied.