Objective:The purpose of this study is to discuss imaging technique of multi-slice spiral CT and its clinical application value in diagnosis of duodenum diseases.Methods:Nineteen patients with duodenum diseases underwent multi-slice CT image either with gaseous distension or drinking water,and correlated with operative findings and pathology.Using GE Light-speed Ultra 16 slice CT to perform whole duodenum scan in the supine and left decubitus positions.reconstruction images of duodenum were done at the console workstation,including MPR and SSD image.Results:CT images of nineteen patients with duodenum diseases can provide valuable in formation.Drinking water was the basic method of duodenum CT,especially for solid tumor in duodenum,and axial images combined with MPR should be the main technique.Success rate of duodenum imaging with gas is lower.But it is helpful for diagnosis of duodenum diverticulum and differentiated diagnosis between duodenum diverticulitis and malignancy,and SSD combined with MPR should be the main technique.Conclusion:MSCT with post-pressing reformation techniques have great value for diagnosis and differential diagnosis of duodenum diseases.