Objective To explore the value of ERCP in diagnosis of obstructive jaundice.Methods The results of ERCP in 526 patients with obstructive jaundice were analyzed.Results There were 506 cases success- fully diagnosed by ERCP and the successful rate was 96%.Among the patients,460 were accurately defined and the rate of accuracy was 91%.About 56% of the patients with obstructive jaundice had intraphepatic and extra- hepatic duct stones.The occurring rate of ERCP complications was 3.4%.Conclusions ERCP is a reliable method to define the causes of obstructive jaundice.Though the first choice for diagnosis of obstructive jaundice is BUS,ERCP should also be used if it is possible.