β_3-adrenergic Receptors and Heart Disease

We used to pay close attention to β_1-adrenergic receptors or β_2-adrenergic receptors between β-adrenergic receptors and heart disease in earlier period,while the study of β_3-receptors was restricted to metabolic disease.The excited β_3-receptors have been described to mediate negative inotropic effects at heart failure in the last years.This article was to give a brief clarification about β_3-receptors and heart disease.