In order to study the interactive guiding relation of HS 300 Stock Index between futures prices and spot prices,this paper makes empirical analysis of 1 320 data in 660 exchange days during April 16th,2010December 28th,2012,and the research results show that there is a cointegration relation of the stock index between futures prices and spot prices,that the change of stock index futures prices has effect on the spot prices after a phase,however,the change of stock index spot prices has effect on the futures prices after two phases,and that there is a weak relation of bidirectional price guidance because the futures prices play a mainly guiding role.