Effect of hepatic stellate cells in liver fibrosis regression

Liver fibrosis is considered as a serious disease,which can lead to portal hypertension,liver cirrhosis and liver failure.It has been well established that the activation of hepatic stellate cells plays a vital role in the hepatic fibrosis.Inhibiting hepatic stellate cells activation and accelerating clearance of hepatic stellate cells are promising strategies against liver fibrosis.In this assay,apoptosis,senescence and the clearance of the activated hepatic stellate cells will be reviewed,which aims to demonstrate the effect of hepatic stellate cells and its mechanism in hepatic fibrosis regression.