Annals of the Rheumatic Diseases

to 71 years with rheumatoid arthritis (21), degenerative joint changes (30), or non-articular rheumatism (46), with "osadrin", a preparation consisting of equal parts of 1 :4-diphenyl-3 :5-dioxypyrazolidine and dimethyl- aminophenyldimethylpyrazolone with the addition of procaine hydrochloride.The average daily dose was 1 ampoule by injection or four to six tablets by mouth for 10 to 40 days.[The dose contained in each ampoule or tablet is not stated.]In a high proportion of cases a significant anti- rheumatic effect of the treatment was demonstrated locally by diminution of pain, muscular spasm, and exudation, and systemically by disappearance of fever and return to normal of the erythrocyte sedimentation rate.The preparation was well tolerated and there was no local tenderness after injection or gastric upset after oral administration.There was no water retention in spite of increased uric acid elimination.The authors state that their results confirm those of German workers who have been using osadrin for well over 5 years.Max Mayer.