汽化
生物医学中的光声成像
材料科学
分子成像
超短脉冲
相变
超声波
相(物质)
超声成像
光学成像
相变
纳米技术
光学
生物医学工程
化学
激光器
物理
声学
工程物理
医学
生物技术
有机化学
体内
生物
量子力学
作者
Qiyang Chen,Jaesok Yu,Kang Kim
标识
DOI:10.1007/s13534-018-0069-0
摘要
Optically-triggered phase-transition droplets have been introduced as a promising contrast agent for photoacoustic and ultrasound imaging that not only provide significantly enhanced contrast but also have potential as photoacoustic theranostic molecular probes incorporated with targeting molecules and therapeutics. For further understanding the dynamics of optical droplet vaporization process, an innovative, methodical analysis by concurrent acoustical and ultrafast optical recordings, comparing with a theoretical model has been employed. In addition, the repeatability of the droplet vaporization-recondensation process, which enables continuous photoacoustic imaging has been studied through the same approach. Further understanding the underlying physics of the optical droplet vaporization and associated dynamics may guide the optimal design of the droplets. Some innovative approaches in preclinical studies have been recently demonstrated, including sono-photoacoustic imaging, dual-modality of photoacoustic and ultrasound imaging, and super-resolution photoacoustic imaging. In this review, current development of optically triggered phase-transition droplets and understanding on the vaporization dynamics, their applications are introduced and future directions are discussed.
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