胰岛
背景(考古学)
激素
胰腺
肠内分泌细胞
内分泌系统
葡萄糖稳态
胰岛素
血清素
内分泌学
胰高血糖素
生物
内科学
受体
医学
小岛
胰岛素抵抗
古生物学
出处
期刊:Elsevier eBooks
[Elsevier]
日期:2019-01-01
卷期号:: 81-90
标识
DOI:10.1016/b978-0-12-800050-2.00004-8
摘要
The presence of serotonin (5-hydroxytryptamine [5-HT]) in pancreatic endocrine cells is well established. Nevertheless, recent advances are only now unraveling the signaling network involving 5-HT that partly regulates the release of hormones emanating from the islets of Langerhans. It is widely accepted that failure of the pancreatic β-cell to release sufficient amounts of insulin is the main culprit in the development of type 2 diabetes, an ongoing global epidemic. In this context, 5-HT signaling may play a crucial role. In fact, serotonin (5-HT) is part of an intricate signaling network regulating release of insulin and glucagon, the main hormones that control lipid and glucose homeostasis. Several studies have focused on the role of 5-HT and signaling through various 5-HT receptors in pancreatic β-cells and effects on overall glucose metabolism. Here, we aim to discuss some of these issues.
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